Malaysia’s government on Thursday raised concerns over a study suggesting that some antibiotics in the same group of antibiotics may be linked to an increased risk of suicidal behaviour.
The study, published in the New England Journal of Medicine, found that patients taking doxycycline and those taking a combination of doxycycline plus an antibiotic such as minocycline had a higher risk of suicide than patients taking a single antibiotic alone.
The study, led by the Singapore-based Singapore National Healthcare Organisation, found that those taking doxycycline had an increased risk of suicide compared to patients on a single antibiotic. The risk appeared to be higher for those taking doxycycline and minocycline.
The researchers from the University of Sydney’s School of Pharmacy said in a statement that the study was “under review” and that the findings “do not indicate that there is an increased risk of suicide with a single course of doxycycline or minocycline combination in combination with an antibiotic”.
The National Health Service in the country said it is investigating the study as part of its wider review of antibiotic-associated risks. It would be the first study to examine the risks of antibiotic use and the risk of suicidal behaviour in Malaysia.
The research team said the results “indicate that the risk of suicide among those taking antibiotics may be increased in some patients,” the statement added.
The study was funded by the National Institute for Health and Care Excellence (NICE) and the British Association for the Study of Antibiotics (BAAS).
Dr Kate Hudson, a spokeswoman for the National Health Service, said: “The study was a ‘real-world example’ of the need to have a robust research-based approach to prevent and treat infections such as malaria.”
The government has yet to answer a number of public questions about the findings.
The Singapore Department of Health on Wednesday welcomed the results.The Singapore Health Sciences Authority said the results “do not reflect the views of the Department of Health and the Department of Health and Social Care,” adding that the research should be “review” as it “has not been conducted in humans”.
The analysis found that the risk of suicide was highest among those taking doxycycline and minocycline, and among those taking a combination of antibiotics such as doxycycline and minocycline. The two antibiotics, which are also used to treat infections, are used to treat pneumonia and urinary tract infections.
The study also found that those taking doxycycline and minocycline had an increased risk of suicidal behaviour, although not always.
The study, led by the Singapore National Healthcare Organisation, was published in the New England Journal of Medicine.
The study was led by the Singapore National Healthcare Organisation.
The University of Sydney’s School of Pharmacy said in a statement that it is investigating the findings as part of its wider review of antibiotic-associated risks.
A spokesperson for the Singapore Department of Health said that the research was “under review” and that the results are not yet evidence for public health.The Singapore Department of Health on Thursday welcomed the results, saying the results “indicate that the risk of suicide among those taking antibiotics may be increased in some patients,” the statement added.The National Health Service in the country said it is investigating the findings as part of its wider review of antibiotic-associated risks.
The Singapore Department of Health on Wednesday welcomed the results, saying the results “indicate that the risk of suicide among those taking antibiotics may be increased in some patients,” the statement added.
Doxycycline is used to treat bacterial infections. Doxycycline treats urinary tract infections, intestinal infections, respiratory infections, eye infections, sexually transmitted infections (like gonorrhoea and syphilis), gum infections, diseases (like periodontitis), and others. Besides this, Doxycycline also treats acne-like lesions caused by rosacea. However, it does not treat facial redness caused by rosacea.
Doxycycline being an antibiotic prevents the growth of bacterial cells (the bad ones!) by preventing the formation of the outer protein layer of bacteria (cell wall) responsible for bacteria's growth and multiplication. It is a broad-spectrum antibiotic, i.e. it acts against various bacteria. It is a bacteriostatic antibiotic, i.e. it stops bacteria growth but does not kill them.
Doxycycline should only be taken if advised by your doctor. It can be taken with or without food but should be consumed at a fixed time for the best results. You should complete the course of Doxycycline as your doctor prescribes for better results. Some common side effects of Doxycycline are nausea (feeling or being sick), vomiting, diarrhoea, etc. Please consult your doctor if these side effects become troublesome.
Doxycycline is pregnancy category D (high risk) medicines, so its use in pregnant and nursing mothers is not recommended. Use of Doxycycline during tooth development (last half of pregnancy, infancy, and childhood up to the age of 8 years) may cause teeth staining (yellow-grey-brown). Do not consume alcohol as it may cause excessive drowsiness when taken along with Doxycycline. Before using Doxycycline, tell your doctor if you ever had an allergy to Doxycycline, have kidney problems, liver problems, swollen food pipe (esophagitis) or muscle disease (myasthenia gravis). Please do not drink alcohol with Doxycycline as it may increase the unpleasant side effects like drowsiness and dizziness.
You should consume plenty of Doxycycline if you are pregnant or are planning to have an baby. It is pregnancy category D medicine, so its use in pregnancy and unless it is not feasible for others (like lactose-intolerant people) is not recommended. Drug Interactions: You may have interactions with Doxycycline, especially with other medications or with certain health conditions (like kidney disease or diabetes). If you have any health conditions, you should not use Doxycycline. It should be used with care to avoid the consumption of alcohol as it may cause excessive drowsiness when taken along with it. Doxycycline should not be used in patients with a history of seizures or with epilepsy as it is a controlled substance. Do not drink alcohol as it may cause drowsiness and dizziness. If you experience symptoms of a mental state such as delusions, especially if they occur, Doxycycline should be stopped and a new mental state such as a new bipolar disorder (like mania) diagnosed at a particular doctor's appointment.Tell your doctor if you drink any of the grapefruit juice while taking Doxycycline. It is not known if Doxycycline can be absorbed through the skin while taking it. grapefruit juice may decrease the absorption of Doxycycline as it takes on to a bad level depending on its color. If you are taking pimozide (Orap), do not take Doxycycline while taking this medicine. It should be taken with care to avoid the consumption of alcohol as it may cause drowsiness when taken along with it. If you experience drowsiness or any symptoms of impaired liver function, take it at regular intervals. If your symptoms do not improve after 3 months of taking Doxycycline, you should consult your doctor so that any possible medical reason may be excluded. Drug Interactions: Drug interactions with Doxycycline may increase the risk of tendonitis (tendon swelling) and bursitis (tenderness of the bursal muscles), which are both serious side effects of Doxycycline. Therefore, it is recommended to avoid Doxycycline while taking this medicine. Please consult your doctor if you experience any changes in your condition, like tendonitis or bursitis, or if you notice any unexpected symptoms.
There are some drug interactions with Doxycycline: You should not take Doxycycline with other medications containing nitroimidazole like amimipramine (a type of nitrofurantoin), ivermectin (verapamil), or others.Doxycycline:Oral use in the treatment of and relief of symptoms of gonorrhea. Causes of gonorrhea: Mycoplasma genitalium, Rocky Mountain spotted fever, and syphilis. Prevention of syphilis: Cheaper than other transmitters. Lower incidence of syphilis in men who have sex with men. Prophylaxis for syphilis: Cheaper as low as 10% of the original brand. Prolonged absence of sex: Use with expertise. For the treatment of syphilis, doxycycline may be used prophylactically to treat syphilitic lymph nodes. For treatment of early syphilitis, doxycycline suppresses the natural conversion of sex hormone into estrogen in the body. For the prevention of syphilitis, doxycycline blocks enzymes that usually contribute to the synthesis of sex hormone-binding protein in the vagina. Doxycycline may be used in combination with other therapies to lessen symptoms. Where syphilitis occurs following therapy with doxycycline, doxycycline is usually used alone. Not suitable for persons with hepatic and cardiovascular disease. Use only when the patient wishes to lessen his or her symptoms.
Doxycycline for the treatment of gonorrhoea:Inhalation of tinea pedis. Lethargy: Doxycycline for the treatment of malaria. Lactation: Doxycycline for the treatment of chlamydiosis. Oral: Doxycycline for the prevention of syphilis. Administration in the form of solution: Doxycycline for the treatment of malaria. Method of administration: Doxycycline for the treatment of chlamydiosis is usually administered orally. However, it is important to follow the instructions of your healthcare provider.
Doxycycline non-pharmacologicalOverdose: Inhalation of tinea pedis may be an effective treatment. Celecoxib pain and inflammation: Infectious monotherapy. Cephalexin: Celecoxib for the treatment of chronic constipation. Doxycycline for the treatment of malaria: Infectious monotherapy. Duration of effect: In hours to weeks after the last dose. Antimalarials: Doxycycline for the treatment of malaria. Acute ototoxic effects: Doxycycline for the treatment of acute ototoxicity. Use only when expense dictates necessary use.
Doxycycline for the treatment of gonorrhoea and malaria. Mental problems: Doxycycline for the treatment of chlamydiosis.
General:
Doxycycline for the treatment of gonorrhoea: Inhalation of tinea pedis. Oral: Doxycycline for the prevention of syphilitis. Administration in the form of solution: Injection by a healthcare provider.
Active ingredient: Doxycycline.
Mental problems: Chlamydiosis. Mental problems: Inhalation of tinea pedis.
Background:There is limited information on the effects of doxycycline on the cardiovascular and metabolic parameters in horses. The purpose of this study was to assess the effect of doxycycline on the metabolic parameters in horses with a normal metabolic state and to determine the clinical significance of the effect of doxycycline on cardiovascular and metabolic parameters in this animal model.
Methods:The study was conducted in a group of 4 mares with a history of chronic kidney disease. The experimental conditions were produced in a single dose of 200 mg doxycycline per day for 14 days, and the animals were then divided into four groups. The four groups were given doxycycline for 14 days. Group A (4-week treatment), which was given doxycycline for 14 days, was administered intravenous oxytetracycline (0.5 mg/kg body weight) for 14 days. Group B (4-week treatment), which was given doxycycline for 14 days, was administered intravenous oxytetracycline (0.5 mg/kg body weight) for 14 days. In Group A, horses with a normal metabolic state and animals with a heart failure state were treated with doxycycline for 14 days, and group B, which was given doxycycline for 14 days, was administered intravenous oxytetracycline (0.5 mg/kg body weight) for 14 days. The study protocol was approved by the institutional Animal Care and Use Committee of the Faculty of Veterinary Medicine, University of Wroclaw. The animals were not used for this study. A total of 12 (4-week treatment) and 12 (4-week treatment) consecutive doses of doxycycline were given intravenously at the beginning of the study.
Results:In group A (4-week treatment), the mean daily dosage (mg/kg body weight) for the 14-day treatment was 200 mg. For the 14-day treatment, the mean daily dosage was 200 mg for 4 weeks, but the mean daily dosage of doxycycline was 400 mg. In group B, the mean daily dosage of the 14-day treatment was 200 mg for 4 weeks, but the mean daily dosage of doxycycline was 400 mg. In Group B, the mean daily dosage of the 14-day treatment was 200 mg for 4 weeks, but the mean daily dosage of doxycycline was 400 mg. The mean daily dose of doxycycline was 400 mg in the four treatment groups.
Conclusions:The mean daily dosage of doxycycline for the 14-day treatment in this study was 200 mg for 4 weeks, but the mean daily dosage of doxycycline was 400 mg for 4 weeks. The mean daily dosage of doxycycline was 400 mg in the four treatment groups.
Table 1 Doxycycline effect on body weights in horses with normal metabolic state in this study (n=4). Doxycycline effect on the cardiovascular and metabolic parameters in horses with a normal metabolic state in this study in the study protocol. Doxycycline effect on the metabolic parameters in horses with a heart failure state in this study. The effect of doxycycline on the cardiovascular and metabolic parameters in horses with a heart failure state. The effect of doxycycline on the metabolic parameters in horses with a normal metabolic state in this study. The effect of doxycycline on the cardiovascular and metabolic parameters in horses with a normal metabolic state in this study.
Stade de France Pharmacy